Hip dysplasia (HD) is a disease affecting a very large number of breeds, especially those of large sizes. This multifactorial disease, has genetic causes that are closely related to external factors (such as the dog’s weight, physical activity …). Hip dysplasia is a complex pathology involving several genes with various gene alterations. Moreover, the combinatorics of these alterations will certainly be different according to the dog breeds studied. However, it can be assumed that in a breed or small group of breeds, a small number of genes will be involved. Studying the molecular basis of dysplasia in different dog breeds will also reveal candidate genes for human congenital dislocations where no gene has yet been clearly identified.The goals of the research project are :
- identify new genes and their mutations
- develop genetic tests for diagnosis and screening
- investigate the involvement of these genes in cases of human congenital dislocation
To identify the genetic basis of dysplasia, we are looking for blood samples from dogs with hip radiographs that have been rated A, B, C, D / E according to the FCI nomenclature. The DNA of these samples will be extracted and entered anonymously into the CaniDNA database
The strategy to identify the genetic causes consists in comparing the genomes (all 38 chromosomes + XY) of a large number of dogs with hip radiographs A and D / E of the same breed to identify the region (s). chromosome (s) containing the gene (s) involved in the dysplasia and the causative mutation (s). The last step corresponds to the validation of the mutations in the race studied, even in phylogenetically related breeds.
In practice, if you wish to participate in this research project, we ask you, during the radiographic screening of hip dysplasia or another visit to your veterinarian, to send us:
- a blood sample on an EDTA tube : CNRS_HD_Protocole
- a clinical questionnaire completed with the help of your veterinarian: CNRS_HD_Questionnaire
- the pedigree copy (if possible and if available)
- a copy of the official reading record of hip and elbow radiography (if available)
We work specifically on the following breeds: Labrador Retriever, Golden Retriever, Bernese Mountain Dog, Great Dane, Brittany Spaniel, Pyrenean Shepherd, Pyrenees Mountain, Setters, Cane Corso, German Shepherd, Weimaraner, Braque of Ariège , Belgian Shepherd, Tervueren, Groendal, Malinois, Newfoundland, Siberian Husky, Alaskan Malamute.
This project is carried out in collaboration with the ACGAO and with the help of many veterinarians, whom we thank especially and thanks to the many owners and breeders who agree to take their dog (s) in this study.
We remind you that the data collected at the CNRS are confidential.
For more information, you can contact our team by phone at 02 23 23 45 09 or by email cani-dna@univ-rennes1.fr.
