Glomerulonephropathy is a common kidney disease in the Dogue de Bordeaux [1] which can cause severe chronic renal failure (CKD) resulting in the death of affected dogs in their first years of life [2]. It is characterized by a loss of more or less protein in the urine of dogs (proteinuria).
Following requests from several breeders, and the clinical work previously carried out by Dr. Rachel Lavoué, we started a research project on the genetic characterization of glomerulonephropathy of the Dogue de Bordeaux, in collaboration with Dr. Rachel Lavoué of the National Veterinary School of Toulouse.
Glomerulonephropathy of the Dogue de Bordeaux can take different forms:
- Juvenile form: the most serious form, with early symptoms (before 2 years of the dog) secondary to severe CKD and proteinuria. Death is common in the first 2 years of the animal’s life [2].
- Moderate or intermediate form: later onset of symptoms (between 2 and 5 years), secondary to a more or less late mild CKD and proteinuria. The speed of evolution is variable [1].
- Subclinical form called “silent”: absence of CKD and absence of clinical symptoms. It is a chronic kidney disease characterized by a proteinuria that increases gradually with age. This form of the disease is insidious [1].
Whatever its clinical presentation, only the realization of renal biopsies can confirm the diagnosis of Glomerulopathy of the Dogue de Bordeaux.
To improve the understanding of the mechanisms involved in the development of this disease, dogs suspected of having this disease, as well as their close relatives (parents, siblings) can help us. Blood and urine samples, which are easily done by most veterinarians and safe for your dogs, are essential for advancing research. If your veterinarian is required to perform kidney biopsies on your dog, it is important to contact us so that we can help you confirm / exclude the suspicion of Glomerulonephropathy of the Dogue de Bordeaux.
If you wish to participate in this research work, you can contact our team by phone at 02 23 23 45 09 or by email cani-dna@univ-rennes1.fr to give you more details on the project and the samples to be taken to participate.
To continue our research, we need:
- blood and urine samples :
CNRS_Glomerulonephropathie_Protocole, CNRS_Glomerulonephropathie_Protocole_Schéma
- a clinical questionnaire completed with the help of your veterinarian :
CNRS_Glomerulonephropathie_Questionnaire
- a photocopy of the pedigree (if possible and if available)
- a photocopy of blood or urine test results
We recall that the data collected at the CNRS remain confidential.
For more information, you can contact our team by phone at 02 23 23 45 09 or by email cani-dna@univ-rennes1.fr.
[1] Lavoue R, Trumel C, Smets PM, Braun JP, Aresu L, Daminet S, et al. Characterization of Proteinuria in Dogue de Bordeaux Dogs, a Breed Predisposed to a Familial Glomerulonephropathy: A Retrospective Study. PLoS One 2015;10:e0133311.
[2] Lavoué R, van der Lugt JJ, Day MJ, Georges M, Busoni V, Merveille AC, et al. Progressive Juvenile Glomerulonephropathy in 16 Related French Mastiff (Bordeaux) Dogs. J. Vet. Intern. Med. 2010;24:314-22.
